Science
Scientific results
The described CrescNet process has produced very significant results. It was and is made possible by the financial commitment of numerous sponsors, who are expressly thanked for their support. Discussions on this can be found in a large number of publications [INTERN].
Early detection
Through CrescNet, the detection of growth and developmental disorders is improved. On average, the patients with proven growth hormone deficiency identified by the screening program at the Treatment Centre at the Clinic for Children and Adolescents at Leipzig University Hospital were able to receive the necessary substitution at least two years earlier [JPG]. ( see list of publications: Die Früherkennung von Wachstumsstörungen - System CrescNet im Behandlungszentrum Leipzig im Deutschen Ärzteblatt)
Reference curves and secular trendDescribed at annual (or shorter if necessary) intervals are the growth and weight trends of the entire child and adolescent population covered. The measured values of body size show only marginal differences [JPG]. to recognised German reference curves according to Kromeyer-Hauschild et al. (2001). The red double lines show the confidence interval for the 3rd, 50th and 97th percentiles from CrescNet data. The blue dashed line denotes the Kromeyer-Hauschild reference percentiles. This picture corresponds to the general observation that body sizes in Central Europe have hardly changed for about 30 years. However, the development of weight is very different from this. The relationship between height and weight is expressed by the body mass index (BMI) and assessed by percentiles. The differences in BMI percentiles [JPG] P3 and P50 to reference data of Kromeyer-Hauschild et al. (2001) are marginal. However, there is an increasing upward deviation towards the 97th percentile (P97) from the fourth year of life onwards. |
▶ Open Reference Data Collection [WEB]
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Monitor for conspicuity rates overweight and obesity
Since CrescNet continuously collects data from practices and clinics, it is possible to determine overweight and obesity rates [JPG] based on age. This is assessed by the Body Mass Index (BMI). A BMI value between the 90th and 97th percentile is considered overweight. If the BMI value in childhood is above the 97th percentile, it is called obesity. You can look at graphs here that record the development of prevalence rates for overweight and obesity since 1999.
Publications of CrescNet
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▼2025: Limb lengthening in individuals with achondroplasia: Analysis of an international survey
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▼2025: Severity of Congenital Heart Defects Affects Long-Term Somatic Development
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▼2023: High but decreasing prevalence of overweight in preschool children: encouragement for further action
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▼2022: Growth Patterns of Children With Short Stature in Adulthood According to Auxological Status and Maturity at Birth
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▼2022: The influence of body mass index on the growth hormone peak response regarding growth hormone stimulation tests in children
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▼2021: Age- and weight group-specific weight gain patterns in children and adolescents during the 15 years before and during the COVID-19 pandemic
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▼2021: COVID-19 pandemic and families utilization of well-child clinics and pediatric practices attendance in Germany
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▼2021: Dynamic alterations in linear growth and endocrine parameters in children with obesity and height reference values
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▼2021: [Primordial prevention in childhood to avoid chronic diseases]
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▼2021: Kinder- und Jugendärzte leisten mit CrescNet-Monitoring einen wichtigen Beitrag für Public Health
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▼2020: Long-term mortality after childhood growth hormone treatment: the SAGhE cohort study
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▼2020: A Comprehensive Cohort Analysis Comparing Growth and GH Therapy Response in IGF1R Mutation Carriers and SGA Children
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▼2018: Acceleration of BMI in Early Childhood and Risk of Sustained Obesity
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▼2018: Growth prediction of small for gestational age infants within the first weeks after birth
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▼2017: Further stabilization and even decrease in the prevalence rates of overweight and obesity in German children and adolescents from 2005 to 2015: a cross-sectional and trend analysis
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▼2017: Growth and Final Height Among Children With Phenylketonuria
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▼2017: Supporting Pediatricians Decision-Making by using CrescNet as Infrastructure
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▼2017: Cystic-fibrosis Related-Diabetes (CFRD) Is Preceded by and Associated With Growth Failure and Deteriorating Lung Function
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▼2017: Cancer Risks in Patients Treated With Growth Hormone in Childhood: The SAGhE European Cohort Study
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▼2015: Psychosocial Well-Being of Adolescents Before and After a 1-Year Telephone-Based Adiposity Prevention Study for Families
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▼2015: Description of the SAGhE Cohort: A Large European Study of Mortality and Cancer Incidence Risks after Childhood Treatment with Recombinant Growth Hormone
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▼2014: Telephone-based adiposity prevention for families with overweight children (T.A.F.F.-Study): one year outcome of a randomized, controlled trial
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▼2014: Clinical evidence-based cutoff limits for GH stimulation tests in children with a backup of results with reference to mass spectrometry
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▼2014: Children and adolescents with type 1 diabetes in Germany are more overweight than healthy controls: results comparing DPV database and CrescNet database
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▼2013: Prevention of childhood obesity: recruiting strategies via local paediatricians and study protocol for a telephone-based counselling programme
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▼2012: Reasons for (non)participating in a telephone-based intervention program for families with overweight children
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▼2011: Früherkennung von Wachstumsstörungen - System CrescNet im Behandlungszentrum Leipzig
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▼2011: Age-specific stabilization in obesity prevalence in German children - a cross sectional study from 1999 to 2008
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▼2009: Gezielte primäre Adipositasprävention bei Kindern. Prevention for obesity in childhood
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▼2008: Secular trends in body mass index in German children and adolescents: a cross-sectional data analysis via CrescNet between 1999 and 2006
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▼2007: Aufbau, klinische Relevanz und Projekte des Wachstumsnetzwerks CrescNet
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▼2005: Grundlagen eines Programms zur Adipositasprävention bei Kindern und Jugendlichen
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▼2004: Fettsucht bei Kindern
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▼2004: System CrescNet: Erkennung von Störungen des Wachstums und der Gewichtsentwicklung sowie Gewinnung aktueller Entwicklungsdaten
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▼2003: Alterations in Height, Weight and Body Mass Index of Newborns, Children and Young Adults in Eastern Germany after German Reunification
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▼2003: Früherkennung von Wachstumsstörungen: CrescNet - ein Beitrag zur Qualitätsicherung in der Kinder- und Jugendmedizin
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▼2002: Adipositas bei Kindern und Jugendlichen in Deutschland
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▼2002: Auxological computer based network for early detection of disorders of growth and weight attainment
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▼2001: Computer-guided, population-based screening system for growth disorders (CrescNet) and on-line generation of normative data for growth and development
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▼2000: Modellprogramm zur Früherkennung und optimalen Behandlung von Störungen des Wachstums und der körperlichen Entwicklung mit Hilfe eines medizinischen Kompetenznetzwerkes
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▼1996: Wachstumsstörungen rechtzeitig erkennen - eine Aufgabe für die praktische Pädiatrie
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▼1996: Instrumentarium zur Diagnostik von wachstumsgestörten Kindern und Jugendlichen
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▼1994: Screening auf Vorliegen einer Wachstumsstörung mit Hilfe des Präzisionsmeßinstrumentes und Systems Dr. Keller